College of Agriculture & Natural Resources Department of Fisheries and Wildlife

Sreeja Sarasamma, Ph.D., is an Assistant Professor in the Department of Fisheries and Wildlife at Michigan State University and a biotechnology researcher with expertise in molecular biology, genomics, CRISPR/Cas genome editing, and aquatic organismal biology. Her research focuses on the genomic regulation of development, reproduction, and life-history strategies, with particular emphasis on germline biology, sex determination, and genetic control in sea lamprey, as well as metabolic and neurodegenerative processes in zebrafish.

Her research integrates genome editing, embryo manipulation, imaging, behavioral analysis, and multi-omics approaches to investigate the molecular mechanisms linking genotype, phenotype, and biological function. In sea lamprey, her work focuses on developing and implementing germline-targeted CRISPR and gene-drive strategies, identifying and validating candidate genetic loci, optimizing genome-editing approaches, and elucidating the genomic and epigenetic mechanisms underlying sex determination and reproductive development. Her research is supported by the Great Lakes Fishery Commission (GLFC) and includes developing and evaluating genetic approaches for generating genetically modified sea lamprey and advancing environmentally responsible strategies for invasive sea lamprey control in the Great Lakes.

In zebrafish, her research investigates molecular mechanisms underlying metabolism, development, and neurodegenerative disease using genetic models, genome editing, behavioral assays, imaging, and multi-omics approaches. Across these systems, her research bridges fundamental discoveries in developmental, reproductive, and molecular genetics with innovative genetic technologies to advance biological understanding and develop sustainable strategies for invasive species management.